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    In a urinalysis, this is a chemical that’s tested for. When leukoctyes, or white blood cells, are present in the urine, they produce this chemical called leukocyte esterase. Sometimes it can be detected even if no white cells are present as they can disintegrate and still leave behind the chemical. The 1+ is just a grading system from 0 (for none found), to 1+, which means a little, 2+, meaning a moderate amount, 3+ meaning quite a lot and 4+, translating to copious amounts. If there is leukocyte esterase present in your urine, chances are you have a urinary tract infection and should be treated for it with antibiotics before it travels to the kidneys, which could result in a very serious issue.

    It’s one of the components of urine analysis basically done to find out if the person has urinary tract infection

    Normally urine doesn’t contain white blood cells (leucocytes ) so we test urine for leucocytes when patient presents with symptoms of UTI

    We do look for blood, leucocytes and nitrate estrase to rule out infection

    So if it’s + 1 on leucocytes estrase it signifies infection and if it’s + 1 nitrate estrase its by gram negative bacteria ( one class of bacteria most commonly responsible for UTI)

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    You have a small increase (1+) in leucocytes in your urine. If coupled with some protein and nitrites, you definitely have a UTI. White cells alone may be significant, or not, depending on your collection techniques.

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    What does “leukocyte esterase ua moderate” mean?

    UA = urinalysis (analysis of urine)

    Leukocyte esterase (LE) = a type of enzyme contained in most leukocytes (white blood cells), tested for on a urine dipstick (first part of a urinalysis)

    The presence of white blood cells in the urine indicates inflammation of some kind. Most commonly, it indicates a urinary tract infection.

    However, there are other causes of LE being present in the urine not due to infection:

    • Such as in interstitial cystitis (inflammation).
    • Also, classically, if someone has taken phenazopyridine (brandnames Pyridium or Azo —the stuff that turns your urine orange), this test will be a false positive: that is, the test will say LE is present in the urine, but actually, this test result is caused by the drug itself. There are some other drugs that cause give a similar false positive result.

    Moderate amount is exactly what it sounds like: there’s a moderate amount of the leukocyte esterase in the urine on a dipstick.

    The urine is typically further analyzed under the microscope when a positive result such as the ‘moderate LE’ is found: visually, the presence of white blood cells is confirmed (or not). If white blood cells are found, the urine is then also typically sent for a urine culture to see if any specific bacteria are found growing in the urine.

    This basically means you have a urinary infection which could be in the bladder or other parts of the urinary tract. See your doctor and get a clinical examination.

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    It means that you have white cells in your urine, which may indicate a UTI, however the bacteria causing the UTI are not nitrate reducing bacteria. There are several different species or strains of bacteria that can cause UTI. Some reduce nitrates some do not.

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    It may indicate a urinary tract infection. If you came to see me because of symptoms such as painful or frequent urination I would give you a prescription for an antibiotic.

    If you have no symptoms and the result was an incidental finding I wouldn’t treat it immediately and send it for culture and see if the results are truly significant.

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    Esterase and Nitrite Positive urines usually mean you have a bacterial bladder infection.

    If the nitrate is negative, you may still have a bladder infection but not with E. COLI (80% of UTI’s are E. Coli). You may have an enterococcus that does not produce nitrites out of nitrates.

    Or you may have a fistula or other damage to your bladder and the white cells are guarding the bladder while healing goes on.

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    Your physician should be telling you, but it’s possible you have a urinary tract infection. Leukocytes are white blood cells, infection fighters.

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    This may be just inflammation, not uncommon in females, but could mean an upcoming infection. Try the following to ease the inflammation.

    Try wearing undies of 100% cotton, and white only, that are not too tight; the same with jeans. Use only white toilet paper. After intercourse, get up, urinate, and wash with a very mild soap, rinse thoroughly, and dry.

    Some females will get irritation from spicy food, as well. Drink plenty of water.

    These simple things should ease any inflammation, and help prevent infection. However, if you are still getting positive nitrites, ask for a microscopic exam of the urine sediment as well there may be a lingering, mild infection.

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